Replaces Prod. #: ALX-350-077
Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.^Immunomodulator.
Product Details
| Alternative Name: | 8α,β-Octahydroindolizidine-1α,2α,8β-triol |
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| Formula: | C8H15NO3 |
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| MW: | 173.2 |
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| CAS: | 72741-87-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, DMSO, methanol or water (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +4°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine
14, 353 (2007),
Abstract;
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res.
47, 69 (2003),
Abstract;
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer
80, 87 (1999),
Abstract;
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem.
268, 9143 (1993),
Abstract;
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Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator: M.J. Humphries, et al.; Cancer Res.
48, 1410 (1988),
Abstract;
Effect of swainsonine on the processing and turnover of lysosomal beta-galactosidase and beta-glucuronidase from mouse peritoneal macrophages: J.E. Tropea, et al.; J. Biol. Chem.
263, 4309 (1988),
Abstract;
Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties: S.L. White, et al.; BBRC
150, 615 (1988),
Abstract;
Effect of trimming inhibitors on the secretion and biological activity of a murine IgE monoclonal antibody: D.A. Granato & J.R. Neeser; Mol. Immunol.
24, 849 (1987),
Abstract;
Swainsonine inhibits glycoprotein degradation by isolated rat liver lysosomes: J.R. Winkler & H.L. Segal; J. Biol. Chem.
259, 15369 (1984),
Abstract;
Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol.
98, 135 (1983),
Abstract;
