Replaces Prod. #: ALX-270-082
A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.
Product Details
| Alternative Name: | D,L-1,2-Anhydro-myo-inositol |
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| Formula: | C6H10O5 |
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| MW: | 162.1 |
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| CAS: | 6090-95-5 |
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| Purity: | ≥96% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (25mg/ml) or in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Product must be stored under argon. |
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| Handling: | Hygroscopic. Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease: Y. Oji, et al.; Brain
143, 1190 (2020),
Application(s): Treatment of iPSC-derived dopaminergic neurons,
Abstract;
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling: C.L. Kuo, et al.; FEBS J.
286, 584 (2019),
Application(s): Treatment of HEK293T cells,
Abstract;
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases: A.R. Margues, et al.; J. Lipid Res.
57, 451 (2016),
Application(s): Inhibition of GBA,
Abstract;
Full Text
Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases: M.J. Ferraz, et al.; FEBS Lett.
590, 716 (2016),
Application(s): Treatment of HEK293T cells,
Abstract;
Normalization of liver glucosylceramide levels in the "Gaucher" mouse by phosphatidylserine injection: S.C. Datta & N.S. Radin; Biochem. Biophys. Res. Commun.
152, 155 (1988),
Abstract;
beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell: D.S. Newburg, et al.; Biochim. Biophys. Acta
877, 121 (1986),
Abstract;
Destruction and resynthesis of mouse beta-glucosidases: A. Hara & N.S. Radin; Biochim. Biophys. Acta
582, 412 (1979),
Abstract;
The Gaucher mouse: differential action of conduritol B epoxide and reversibility of its effects: M.C. Stephens, et al.; J. Neurochem.
30, 1023 (1978),
Abstract;
Mechanism of action of glycoside-splitting enzymes. V. Labelling of the active center of beta-glucosidases A and B from sweet almond emulsin with (3H)6-bromo-6-deoxyconduritol B epoxide: G. Legler; Hoppe-Seyler's Z. Physiol. Chem.
351, 25 (1970),
Abstract;
