Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

MK-571 . sodium salt

Leukotriene receptor ligand
BML-RA109-0005 5 mg 73.00 USD
BML-RA109-0025 25 mg 299.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-340-021

A potent, selective, orally active leukotriene D4 antagonist. Ki=2.1 nM for inhibition of [3H]-LTD4 binding to human lung membranes. Competitively antagonizes contractions of guinea pig trachea and ileum and human trachea induced by LTD4. Blocks LTD4 and ascaris-induced bronchoconstriction in conscious squirrel monkeys.

Product Details

Alternative Name:L660,711
Formula:C26H26ClN2O3S2 . Na
Purity:≥90% (HPLC)
Appearance:Off-white solid.
Solubility:Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

A reversal in sensory processing accompanies ongoing ecological divergence and speciation in Rhagoletis pomonella: C.Tait, et al.; Proc. Biol. Sci. 288, 192 (2021), Abstract;
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity: F. Bieczynski, et al.; FEBS Lett. 595, 828 (2021), Application(s): Treatment of zebrafish embryos, Abstract;
Overexpression of ABCC1 Confers Drug Resistance to Betulin: X. Chen, et al.; Front. Oncol. 11, 640656 (2021), Application(s): Cell treatment (carcinoma cell lines: HEK293), Abstract; Full Text
Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae: R. Topci, et al.; Sci. Rep. 11, 14258 (2021), Abstract;
Uptake and metabolism of sulphated steroids by the blood–brain barrier in the adult male rat: M.Z. Qaiser, et al.; J. Neurochem. 142, 672 (2017), Abstract; Full Text
Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci. 105, 343 (2016), Application(s): Positive control, Abstract;
The Interactions of P-Glycoprotein with Antimalarial Drugs, Including Substrate Affinity, Inhibition and Regulation: S.M. Senarathna, et al.; PLoS One 11, e0152677 (2016), Application(s): Cell culture, Abstract; Full Text
The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters: J.P. Rigalli, et al.; Cancer Lett. 376, 165 (2016), Application(s): Cell culture, Abstract;
Fast neuronal labeling in live tissue using a biocytin conjugated fluorescent probe: M. Harsløf, et al.; J. Neurosci. Methods 253, 101 (2015), Application(s): Cell Culture, Abstract;
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2: K. Takabe, et al.; J. Biol. Chem. 285, 10477 (2010), Abstract;
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells: U. Stein, et al.; Int. J. Cancer 97, 751 (2002), Abstract;
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic: J. Liu, et al.; Mol. Pharmacol. 60, 302 (2001), Abstract;
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?: K. Jones, et al.; Aids 15, 1353 (2001), Abstract;
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide: L. Vernhet, et al.; Biochem. Pharmacol. 61, 1387 (2001), Abstract;
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; Biochem. Biophys. Res. Commun. 208, 345 (1995), Abstract;
Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist: T.R. Jones, et al.; Can. J. Physiol. Pharmacol. 67, 17 (1989), Abstract;

Related Literature

Product Flyers
Detect Activity of Major ABC Transporter Proteins
Detect Activity of Major ABC Transporter Proteins
Download as PDF

All new literature pieces

Recommend this page

Keep in touch

©2021 Enzo Life Sciences, Inc.,