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MK-571 . sodium salt

Leukotriene receptor ligand
 
BML-RA109-0005 5 mg 79.00 USD
 
BML-RA109-0025 25 mg 322.00 USD
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Replaces Prod. #: ALX-340-021

A potent, selective, orally active leukotriene D4 antagonist. Ki=2.1 nM for inhibition of [3H]-LTD4 binding to human lung membranes. Competitively antagonizes contractions of guinea pig trachea and ileum and human trachea induced by LTD4. Blocks LTD4 and ascaris-induced bronchoconstriction in conscious squirrel monkeys.

Product Details

Alternative Name:L660,711
 
Formula:C26H26ClN2O3S2 . Na
 
MW:537
 
CAS:115104-28-4
 
Purity:≥90% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 2 months at -20°C.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter: D. Vagiannis, et al.; Toxicol. Appl. Pharmacol. 434, 115823 (2022), Abstract;
A reversal in sensory processing accompanies ongoing ecological divergence and speciation in Rhagoletis pomonella: C.Tait, et al.; Proc. Biol. Sci. 288, 192 (2021), Abstract;
Chemical effects on dye efflux activity in live zebrafish embryos and on zebrafish Abcb4 ATPase activity: F. Bieczynski, et al.; FEBS Lett. 595, 828 (2021), Application(s): Treatment of zebrafish embryos, Abstract;
Overexpression of ABCC1 Confers Drug Resistance to Betulin: X. Chen, et al.; Front. Oncol. 11, 640656 (2021), Application(s): Cell treatment (carcinoma cell lines: HEK293), Abstract; Full Text
Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae: R. Topci, et al.; Sci. Rep. 11, 14258 (2021), Abstract;
Uptake and metabolism of sulphated steroids by the blood–brain barrier in the adult male rat: M.Z. Qaiser, et al.; J. Neurochem. 142, 672 (2017), Abstract; Full Text
Increased Systemic Exposure of Methotrexate by a Polyphenol-Rich Herb via Modulation on Efflux Transporters Multidrug Resistance-Associated Protein 2 and Breast Cancer Resistance Protein: C.P. Yu, et al.; J. Pharm. Sci. 105, 343 (2016), Application(s): Positive control, Abstract;
The Interactions of P-Glycoprotein with Antimalarial Drugs, Including Substrate Affinity, Inhibition and Regulation: S.M. Senarathna, et al.; PLoS One 11, e0152677 (2016), Application(s): Cell culture, Abstract; Full Text
The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters: J.P. Rigalli, et al.; Cancer Lett. 376, 165 (2016), Application(s): Cell culture, Abstract;
Fast neuronal labeling in live tissue using a biocytin conjugated fluorescent probe: M. Harsløf, et al.; J. Neurosci. Methods 253, 101 (2015), Application(s): Cell Culture, Abstract;
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2: K. Takabe, et al.; J. Biol. Chem. 285, 10477 (2010), Abstract;
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells: U. Stein, et al.; Int. J. Cancer 97, 751 (2002), Abstract;
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic: J. Liu, et al.; Mol. Pharmacol. 60, 302 (2001), Abstract;
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?: K. Jones, et al.; Aids 15, 1353 (2001), Abstract;
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide: L. Vernhet, et al.; Biochem. Pharmacol. 61, 1387 (2001), Abstract;
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; Biochem. Biophys. Res. Commun. 208, 345 (1995), Abstract;
Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist: T.R. Jones, et al.; Can. J. Physiol. Pharmacol. 67, 17 (1989), Abstract;

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