Potent lipoxin A4 agonist, equiactive as LXA4 in inhibition of LTB4 induced PMNL chemotaxis (IC50=5 nM).
Product Details
| Alternative Name: | 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester |
| |
| Formula: | C8H16O5 |
| |
| MW: | 192.2 |
| |
| Purity: | ≥99% |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms: F. Lin, et al.; Reprod. Toxicol.
34, 677 (2012),
Application(s): Injection of BML-111 in low-dose endotoxin induced preeclampsia in rats,
Abstract;
Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of anti-angiogenesis: Y. Chen, et al.; Mol. Cancer Res.
9, 2164 (2010),
Application(s): Injection of BML-111 in tumor-transplanted mice,
Abstract;
Full Text
BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis: L. Zhang, et al.; Inflamm. Res.
57, 157 (2008),
Application(s): Injection of BML-111 in a murine model of collagen-induced arthritis,
Abstract;
Protective effects of BML-111, a lipoxin A4 receptoir agonist, on carbon tetrachloride-induced liver injury in mice: L. Zhang, et al.; Hepatol. Res.
37, 948 (2007),
Application(s): Injection of BML-111 a murine model of carbon tetrachloride (CCl4)-induced acute liver injury,
Abstract;
