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BML-111

Lipoxin receptor ligand
 
BML-RA108-0001 1 mg 73.00 USD
 
BML-RA108-0005 5 mg 291.00 USD
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Potent lipoxin A4 agonist, equiactive as LXA4 in inhibition of LTB4 induced PMNL chemotaxis (IC50=5 nM).

Product Specification

Alternative Name:5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
 
Formula:C8H16O5
 
MW:192.2
 
Purity:≥99%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
BML-RA108 structure
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BML-RA108 structure

Product Literature References

Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms: F. Lin, et al.; Reprod. Toxicol. 34, 677 (2012), Application(s): Injection of BML-111 in low-dose endotoxin induced preeclampsia in rats, Abstract;
Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of anti-angiogenesis: Y. Chen, et al.; Mol. Cancer Res. 9, 2164 (2010), Application(s): Injection of BML-111 in tumor-transplanted mice, Abstract; Full Text
BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis: L. Zhang, et al.; Inflamm. Res. 57, 157 (2008), Application(s): Injection of BML-111 in a murine model of collagen-induced arthritis, Abstract;
Protective effects of BML-111, a lipoxin A4 receptoir agonist, on carbon tetrachloride-induced liver injury in mice: L. Zhang, et al.; Hepatol. Res. 37, 948 (2007), Application(s): Injection of BML-111 a murine model of carbon tetrachloride (CCl4)-induced acute liver injury, Abstract;

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