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SQ-29548

Thromboxane receptor ligand



BML-RA103-0001	1 mg	150.00 USD
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Replaces Prod. #: ALX-340-016

Potent, selective thromboxane A₂ receptor antagonist. Shows inhibition of human platelet aggregation initiated by arachidonic acid (IC₅₀=12nM) . K_i=7.9 nM for inhibition of [³H]-U-46619 binding to human platelet membranes.

Product Details

Alternative Name:	[1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(Phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptanoic acid]

Formula:	C₂₁H₂₉N₃O₄

MW:	387.5

CAS:	98672-91-4

Purity:	≥98% (HPLC)

Appearance:	White to off-white crystalline powder.

Solubility:	Soluble in 100% ethanol, methanol or acetonitrile; also soluble in PBS, pH 7.2, DMSO or dimethyl formamide.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Handling:	Hygroscopic.

Technical Info/Product Notes:	Note: Product is not sterile.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Effect of hypoxia in mice mesenteric arteries surrounded by adipose tissue: N. Maenhaut, et al.; Acta Physiol. (Oxf.) 203, 235 (2011), Abstract;

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells: M. Fukunaga, et al.; Am. J. Physiol. 264, C1619 (1993), Abstract;

7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors: M. Naka, et al.; J. Pharmacol. Exp. Ther. 262, 632 (1992), Abstract;

Characterization of binding of a specific antagonist, [3H]-SQ 29,548, to soluble thromboxane A2/prostaglandin H2 (TP) receptors in human platelet membranes: H. Monshizadegan, et al.; Life Sci. 51, 431 (1992), Abstract;

Characterization of the thromboxane receptor mediating prostacyclin release from cultured endothelial cells: J.A. Hunt, et al.; Biochem. Pharmacol. 43, 1747 (1992), Abstract;

Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles: M.L. Ogletree & G.T. Allen; J. Pharmacol. Exp. Ther. 260, 789 (1992), Abstract;

PgH2 analogs as potential antiplatelet derivatives: D. Komiotis, et al.; J. Med. Chem. 35, 3033 (1992), Abstract;

Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548): E.J. Kattelman, et al.; Thromb Res. 41, 471 (1986), Abstract;

Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist: M.L. Ogletree, et al.; J. Pharmacol. Exp. Ther. 234, 435 (1985), Abstract;