Replaces Prod. #: ALX-340-016
Potent, selective thromboxane A2 receptor antagonist. Shows inhibition of human platelet aggregation initiated by arachidonic acid (IC50=12nM) . Ki=7.9 nM for inhibition of [3H]-U-46619 binding to human platelet membranes.
Product Details
Alternative Name: | [1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(Phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptanoic acid] |
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Formula: | C21H29N3O4 |
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MW: | 387.5 |
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CAS: | 98672-91-4 |
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Purity: | ≥98% (HPLC) |
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Appearance: | White to off-white crystalline powder. |
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Solubility: | Soluble in 100% ethanol, methanol or acetonitrile; also soluble in PBS, pH 7.2, DMSO or dimethyl formamide. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Handling: | Hygroscopic. |
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Technical Info/Product Notes: | Note: Product is not sterile. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effect of hypoxia in mice mesenteric arteries surrounded by adipose tissue: N. Maenhaut, et al.; Acta Physiol. (Oxf.)
203, 235 (2011),
Abstract;
Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells: M. Fukunaga, et al.; Am. J. Physiol.
264, C1619 (1993),
Abstract;
7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors: M. Naka, et al.; J. Pharmacol. Exp. Ther.
262, 632 (1992),
Abstract;
Characterization of binding of a specific antagonist, [3H]-SQ 29,548, to soluble thromboxane A2/prostaglandin H2 (TP) receptors in human platelet membranes: H. Monshizadegan, et al.; Life Sci.
51, 431 (1992),
Abstract;
Characterization of the thromboxane receptor mediating prostacyclin release from cultured endothelial cells: J.A. Hunt, et al.; Biochem. Pharmacol.
43, 1747 (1992),
Abstract;
Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles: M.L. Ogletree & G.T. Allen; J. Pharmacol. Exp. Ther.
260, 789 (1992),
Abstract;
PgH2 analogs as potential antiplatelet derivatives: D. Komiotis, et al.; J. Med. Chem.
35, 3033 (1992),
Abstract;
Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548): E.J. Kattelman, et al.; Thromb Res.
41, 471 (1986),
Abstract;
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist: M.L. Ogletree, et al.; J. Pharmacol. Exp. Ther.
234, 435 (1985),
Abstract;