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United States 

LY 171883

Leukotriene D4 antagonist
BML-RA101-0010 10 mg 100.00 USD
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Replaces Prod. #: ALX-340-026

Selective, orally active leukotriene D4 antagonist. Has been shown to bind to the γ-isoform of the peroxisome proliferator-activated receptor (PPARγ).

Product Details

Alternative Name:Tomelukast
Purity:≥90% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Organic stock solutions are stable for at least six months when stored at -20°C.
Regulatory Status:RUO - Research Use Only
BML-RA101 structure
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BML-RA101 structure

Product Literature References

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract;
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995), Abstract;
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994), Abstract;
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993), Abstract;
In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist: D.W. Snyder, et al.; J. Pharmacol. Exp. Ther. 243, 548 (1987), Abstract;
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985), Abstract;