| Alternative Name: | Ubiquitin-specific protease 15 |
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| Host: | Rabbit |
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| Immunogen: | Recombinant human USP15 (aa 724-952). |
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| UniProt ID: | Q9Y4E8 |
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| Species reactivity: | Human, Mouse
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| Applications: | WB
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| Formulation: | Liquid. In serum containing 0.01% sodium azide as a preservative. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Ubiquitin-specific protease 15 (USP15) contains the highly conserved Cys and His boxes present in all members of the UBP family of deubiquitinating enzymes. USP15 shares 60.5% sequence identity and 76% sequence similarity with the human homolog (UNP/Unph/USP4) of the mouse Unp proto-oncogene. USP15 can be co-purified with the human CSN complex. Detailed analysis reveals a novel Zinc (Zn)-finger in USP15 and related USPs. Mutation of a single conserved cysteine residue in the predicted Zn binding motif results in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn-finger is essential for the cleavage of poly-Ub chains. |
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| Regulatory Status: | RUO - Research Use Only |
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