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NUB1 (human) polyclonal antibody

BML-PW9685-0025 25 µl 119.00 USD
BML-PW9685-0100 100 µl 384.00 USD
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Product Specification

Alternative Name:NUB1L, NEDD8 ultimate buster 1
Immunogen:Synthetic peptide corresponding to aa 599-615 of human NUB1L.
UniProt ID:Q9Y5A7
Source:Purified from rabbit serum.
Species reactivity:Human
Formulation:Liquid. In PBS containing 0.01% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:NUB1 (NEDD8 Ultimate Buster-1) is a negative regulator of the NEDD8 conjugation system and recruits NEDD8 and its conjugates to the proteasome for degradation. It is also an interferon-inducible protein predominately localized in the nucleus. NUB1 is a strong down-regulator of NEDD8 expression and appears to play a critical role in regulating biological events, including cell growth.
Regulatory Status:RUO - Research Use Only

Product Literature References

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways: G. Liu, et al.; Oncogene 29, 2252 (2010), Application(s): WB and ICC using human (H1299) cells, Abstract;

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