Product Specification
| Alternative Name: | NUB1L, NEDD8 ultimate buster 1 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 599-615 of human NUB1L. |
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| UniProt ID: | Q9Y5A7 |
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| Source: | Purified from rabbit serum. |
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| Species reactivity: | Human
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| Applications: | WB
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| Formulation: | Liquid. In PBS containing 0.01% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | NUB1 (NEDD8 Ultimate Buster-1) is a negative regulator of the NEDD8 conjugation system and recruits NEDD8 and its conjugates to the proteasome for degradation. It is also an interferon-inducible protein predominately localized in the nucleus. NUB1 is a strong down-regulator of NEDD8 expression and appears to play a critical role in regulating biological events, including cell growth. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways: G. Liu, et al.; Oncogene
29, 2252 (2010),
Application(s): WB and ICC using human (H1299) cells,
Abstract;
