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Proteasome 20S β5 subunit (human) polyclonal antibody

BML-PW8895-0025 25 µl 141.00 USD
BML-PW8895-0100 100 µl 443.00 USD
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Product Details

Alternative Name:Proteasome subunit β type-5, Macropain ε chain, Proteasome chain 6, Proteasome subunit MB1, Proteasome subunit X
Immunogen:Synthetic peptide corresponding to aa 194-207 of human proteasome 20S (β5 subunit).
UniProt ID:P28074
Gene/Protein Identifier:PSMB5 (gene name)
Source:Purified from rabbit serum.
Species reactivity:Human
Specificity:Recognizes human proteasome 20S β5 subunit.
Applications:IHC, WB
Formulation:Liquid. In PBS containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Blue Ice
Long Term Storage:-20°C
Technical Info/Product Notes:Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins.
Regulatory Status:RUO - Research Use Only

Product Literature References

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator: M.A. Vasilopoulou, et al.; Redox Biol. 56, 10262 (2022), Abstract;
High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors: L. Besse, et al.; Cells 10, 2853 (2021), Abstract;
Immobilized Antibodies on Mercaptophenylboronic Acid Monolayers for Dual-Strategy Detection of 20S Proteasome: M.M. Barsan, et al.; Sensors 21, 2702 (2021), Abstract; Full Text
An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice: T. Homma & J. Fujii; Biochim. Biophys. Acta Gen. Subj. 1863, 1108 (2019), Application(s): Mouse cryosectioned tissue, Abstract;
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons: R. van der Kant, et al.; Cell Stem Cell 24, 363 (2019), Application(s): Western blot, Abstract; Full Text
Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma: D. Brunnert, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1666 (2019), Abstract;
Involvement of the ubiquitin-proteasome system in the expression of extracellular matrix genes in retinal pigment epithelial cells: J.E. Ramos de Carvalho, et al.; Biochem. Biophys. Rep. 13, 83 (2018), Abstract;
Modulation of the Proteasome Pathway by Nano-Curcumin and Curcumin in Retinal Pigment Epithelial Cells: J.E. Ramos de Carvalho, et al.; Ophthalmic Res. 59, 98 (2018), Abstract;
Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease: P. Warang, et al.; Br. J. Haematol. 182, 559 (2018), Abstract;
A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function: K.V. Ramachandran, et al.; Nat. Struct. Mol. Biol. 24, 419 (2017), Abstract; Full Text
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids: M. Zhu, et al.; Bioorg. Med. Chem. 25, 2901 (2017), Abstract; Full Text
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens: A.Y. Chang, et al.; J. Clin. Invest. 127, 2705 (2017), Abstract; Full Text
Detection of active proteasome structures in brain extracts: proteasome features of August rat brain with violations in monoamine metabolism: P.A. Erokhov, et al.; Oncotarget 8, 70695 (2017), Abstract; Full Text
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?: G. Palmieri, et al.; J. Alzheimers Dis. 60, 1097 (2017), Abstract;
Proteasome Activation by Small Molecules: Y. Leestemaker, et al.; Cell Chem. Biol. 24, 725 (2017), Abstract;
Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells: M. Kapetanou, et al.; Free Radic. Biol. Med. 103, 226 (2017), Abstract;
The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin: B.A. Zieba, et al.; J. Dermatol. Sci. 88, 10 (2017), Abstract;
Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts: A. Desvergne, et al.; Free Radic. Biol. Med. 94, 195 (2016), Application(s): Western blot, Abstract;
Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection: M.K. McCarthy, et al.; Virology 498, 57 (2016), Abstract; Full Text
Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models: F.F. Corrales-Medina, et al.; Leuk. Res. 39, 371 (2015), Application(s): Western Blotting, Abstract;
Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux: L.M. Bollinger, et al.; Obesity (Silver Spring) 23, 1185 (2015), Application(s): Western Blot, Abstract; Full Text
SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes: T. Homma, et al.; Arch. Biochem. Biophys. 583, 65 (2015), Application(s): Immunoblotting, Abstract;
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells: Y.N. Rui, et al.; Autophagy 11, 812 (2015), Abstract; Full Text
Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity: A. Belogurov Jr, et al.; FASEB J. 29, 1901 (2015), Abstract; Full Text
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a: A. Sparks, et al.; Oncogene 33, 4685 (2014), Application(s): WB using human cell lysates, Abstract; Full Text
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract; Full Text
Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons: Q. Huang, et al.; J. Biol. Chem. 288, 12161 (2013), Abstract;
Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer: K.R. Cron, et al.; PLoS One 8, e73710 (2013), Application(s): Western blot, Abstract; Full Text
Proteasome inhibitors protect the steatotic and non-steatotic liver graft against cold ischemia reperfusion injury: M.A. Zaouali, et al.; Exp. Mol. Pathol. 94, 352 (2013), Application(s): Western blot, Abstract;
RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells: P. Bergamo, et al.; PLoS One 8, e80900 (2013), Application(s): Western blot, Abstract; Full Text
A putative role for the immunoproteasome in the maintenance of pluripotency in human embryonic stem cells: S.P. Atkinson, et al.; Stem Cells 30, 1373 (2012), Application(s): Western blot, Abstract; Full Text
Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy: P. Balsas, et al.; Leuk. Res. 36, 212 (2012), Application(s): Western blot, Abstract;
Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62: N. Myeku, et al.; J. Biol. Chem. 286, 22426 (2011), Application(s): Western blot, Abstract; Full Text
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions: Z. Lukic, et al.; Retrovirology 8, 93 (2011), Abstract; Full Text

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