Product Details
| Alternative Name: | Proteasome subunit β type-7, Macropain chain Z |
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| Clone: | MCP168 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Dinitrophenylated proteasomes. |
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| UniProt ID: | Q99436 |
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| Gene/Protein Identifier: | PSMB7 (gene name) |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
Yeast
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| Specificity: | Recognizes the β2 subunit of proteasome 20S. |
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| Applications: | IHC, WB
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| Purity Detail: | Protein G-affinity purified ascites. |
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| Formulation: | Liquid. In PBS containing 10mM sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins. |
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| Regulatory Status: | RUO - Research Use Only |
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Western Blot analysis of BML-PW8145: Lane 1: SeeBlueTMPlus2 MW Marker, Lane 2: HeLa cell lysate (Prod. No. ADI-LYC-HL100), Lane 3: Jurkat cell lysate (Prod. No. ADI-LYC-JK100).
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Product Literature References
Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator: M.A. Vasilopoulou, et al.; Redox Biol.
56, 10262 (2022),
Abstract;
Curative Treatment of POMP-Related Autoinflammation and Immune Dysregulation (PRAID) by Hematopoietic Stem Cell Transplantation: A. Meinhardt, et al.; J. Clin. Immunol.
41, 1664 (2021),
Abstract;
Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma: D. Brunnert, et al.; Biochim. Biophys. Acta Mol. Basis Dis.
1865, 1666 (2019),
Abstract;
Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome: K.V. Ramachandran, et al.; Mol. Cell
71, 169 (2018),
Abstract;
Full Text
Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells: M. Kapetanou, et al.; Free Radic. Biol. Med.
103, 226 (2017),
Abstract;
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells: Y.N. Rui, et al.; Autophagy
11, 812 (2015),
Abstract;
Full Text
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget
5, 6252 (2014),
Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay,
Abstract;
Full Text
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions: Z. Lukic, et al.; Retrovirology
8, 93 (2011),
Abstract;
Full Text
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