Product Details
| Alternative Name: | Proteasome subunit α type-3, Macropain subunit C8 |
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| Clone: | MCP72 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Dinitrophenylated human placenta derived proteasomes. |
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| UniProt ID: | P25788 |
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| Gene/Protein Identifier: | PSMA3 (gene name) |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human, Rat
Arthropod, Rabbit, Yeast
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| Specificity: | Recognizes the α7 subunit of the 20S proteasome. |
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| Applications: | IHC, WB
|
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| Purity Detail: | Partially purified ascites. |
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| Formulation: | Liquid. In PBS containing 10mM sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator: M.A. Vasilopoulou, et al.; Redox Biol.
56, 10262 (2022),
Abstract;
Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models: K.W. Geijtenbeek, et al.; PLoS One
17, e0278130 (2022),
Abstract;
Reduced lung cancer burden by selective immunomodulators elicits improvements in muscle proteolysis and strength in cachectic mice: A. Salazar-Degracia, et al.; J. Cell. Physiol.
234, 18041 (2019),
Abstract;
Effects of the beta2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia: A. Salazar-Degracia, et al.; Biochimie
149, 79 (2018),
Abstract;
Involvement of the ubiquitin-proteasome system in the expression of extracellular matrix genes in retinal pigment epithelial cells: J.E. Ramos de Carvalho, et al.; Biochem. Biophys. Rep.
13, 83 (2018),
Abstract;
Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro: S.K. Shin, et al.; Exp. Mol. Med.
49, e287 (2017),
Abstract;
Full Text
Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells: M. Kapetanou, et al.; Free Radic. Biol. Med.
103, 226 (2017),
Abstract;
Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality: C.W. Baumann, et al.; PLoS One
11, e0160839 (2016),
Application(s): Western blot, left soleus muscles,
Abstract;
Full Text
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun.
7, 10963 (2016),
Application(s): Western blot,
Abstract;
Time-Course of Muscle Mass Loss, Damage, and Proteolysis in Gastrocnemius following Unloading and Reloading: Implications in Chronic Diseases: A. Chacon-Cabrera, et al.; PLoS One
11, e0164951 (2016),
Application(s): Immunoblotting of 1D electrophoresis, frozen mouse muscle samples,
Abstract;
Full Text
Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure: D.S. Pitcher, et al.; EBioMedicine
2, 642 (2015),
Application(s): Western Blot,
Abstract;
p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53: H. Yan, et al.; Cell Death Dis.
6, e1662 (2015),
Application(s): Western Blotting,
Abstract;
Full Text
Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE): D.S. Pitcher, et al.; Biochim. Biophys. Acta
1844, 2222 (2014),
Abstract;
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions: Z. Lukic, et al.; Retrovirology
8, 93 (2011),
Abstract;
Full Text
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