| Alternative Name: | TRP53, Tumor protein p53 |
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| Clone: | EX-1 |
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| Host: | Mouse |
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| Isotype: | IgG |
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| Immunogen: | Recombinant full length human p53. |
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| UniProt ID: | P04637 |
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| Species reactivity: | Human
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| Specificity: | Recognizes a C-terminal epitope of human p53. This epitope contains the p53 SUMO (K386) and NEDD8 (K370, K372, K373) modification site residues along with all its potential C-terminal ubiquitinylation sites. |
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| Applications: | WB
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| Formulation: | Liquid. In PBS containing 0.09% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | p53 is a much studied and complex multifunctional protein, which plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis, through its involvement in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for these processes. Activation and regulation of the p53 transcription pathway is controlled by a range of post-translational modifications including acetylation, phosphorylation, ubiquitinylation and SUMOylation. |
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| Regulatory Status: | RUO - Research Use Only |
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