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USP30 (human) polyclonal antibody

BML-PW0975-0025 25 µl 119.00 USD
BML-PW0975-0100 100 µl 330.00 USD
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Product Specification

Alternative Name:Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Deubiquitinating enzyme 30, Ub-specific protease 30
Immunogen:Synthetic peptide corresponding to aa 170-185 of human USP30.
UniProt ID:Q70CQ3
Source:Whole rabbit serum.
Species reactivity:Human
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. Crude serum containing 0.1% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:USP30 (ubiquitin specific protease 30) is a 517 amino acid deubiquitinylating enzyme that localizes to the mitochondrion (embedded in the outer mitochondrial membrane). Depletion of USP30 expression by RNA interference induces elongated and interconnected mitochondria, without changing the expression levels of the key regulators for mitochondrial dynamics, suggesting a key role for USP30 in regulating mitochondrial morphology.

USP30 has also been shown to be necessary for certain aspects of the hepatocyte growth factor (HGF)-dependent scattering response of epithelial cells, indicating that USP30 could be a potential target for therapeutic intervention to prevent metastasis.
Regulatory Status:RUO - Research Use Only
USP30 (human) polyclonal antibody Western blot
Figure: Detection of USP30 in human liver cell mitochondrial preparation (2.5µg) by Western blot using USP30 (human), pAb (Prod. No. BML-PW0975) (1:1’000).
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USP30 (human) polyclonal antibody Western blot

General Literature References

Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells: R. Buus et al.; Curr. Biol. 19, 1463 (2009), Abstract;
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane: N. Nakamura & S. Hirose; Mol. Biol. Cell. 19, 1903 (2008), Abstract;

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