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Huntingtin polyclonal antibody

BML-PW0595A-0025 25 µg 142.00 USD
BML-PW0595A-0100 100 µg 459.00 USD
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Replaces Prod. #: BML-PW0595

Product Details

Alternative Name:Htt, HD Protein
Immunogen:Synthetic peptide corresponding to aa 2-17 of human huntingtin.
UniProt ID:P42858
Source:Purified from rabbit serum.
Species reactivity:Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~350kDa by Western blot.
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene (>35 repeats results in HD onset). Expansion of this polyglutamine repeat may induce a toxic gain of function perhaps through interactions with other cellular proteins. The huntingtin protein is thought to be necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. SUMO modification at the N-terminus of the huntingtin protein is also believed to play a role in the neurodegenerative process.
Regulatory Status:RUO - Research Use Only
Huntingtin polyclonal antibody Western blot
Western blot analysis of Huntingtin pAb (Prod. No. BML-PW0595A): Lane 1: MW Marker, Lane 2: Mouse Brain Tissue Extract (Prod. No. ADI-LYT-MB100), Lane 3: Rat Brain Tissue Extract (Prod. No. ADI-LYT-RB100).
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Huntingtin polyclonal antibody Western blot

General Literature References

Global changes to the ubiquitin system in Huntington’s disease: E.J. Bennett, et al.; Nature 448, 704 (2007), Abstract;
Huntington’s disease: the challenge for cell biologists: A.J. Tobin & E.R. Signer; Trends Cell Biol. 10, 531 (2000), Abstract;
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. The Huntington’s Disease Collaborative Research Group: Cell 72, 971 (1993), Abstract;

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