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Sp100 (SUMO modified) (human) polyclonal antibody

BML-PW0330-0025 25 µl 110.00 USD
BML-PW0330-0100 100 µl 330.00 USD
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Product Specification

Immunogen:Synthetic peptide corresponding to aa 292-304 of human SP100, SUMO modified at Lys297.
UniProt ID:P23497
Species reactivity:Human
Specificity:Recognizes human SUMO-Sp100.
Crossreactivity:Does not cross-react with unmodified Sp100 under native conditions.
Formulation:Liquid. In PBS containing 0.01% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Sp100 is an interferon-inducible protein and a major constituent of distinct nuclear domains, known as nuclear dots (NDs) or PML bodies. NDs play a role in autoimmunity, virus infections, and in the etiology of acute promyelocytic leukaemia. SUMO modification of Sp100 has been shown to promote interaction of Sp100 with non-histone chromosomal proteins, suggesting a regulatory role in chromatin organization and in functional interplay between these nuclear bodies and chromatin.
Regulatory Status:RUO - Research Use Only

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