Host: | Rabbit |
|
Immunogen: | Synthetic peptide corresponding to aa 292-304 of human SP100, SUMO modified at Lys297. |
|
UniProt ID: | P23497 |
|
Species reactivity: | Human
|
|
Specificity: | Recognizes human SUMO-Sp100. |
|
Crossreactivity: | Does not cross-react with unmodified Sp100 under native conditions. |
|
Applications: | ICC
|
|
Formulation: | Liquid. In PBS containing 0.01% sodium azide. |
|
Handling: | Avoid freeze/thaw cycles. |
|
Shipping: | Shipped on Blue Ice |
|
Long Term Storage: | -20°C |
|
Scientific Background: | Sp100 is an interferon-inducible protein and a major constituent of distinct nuclear domains, known as nuclear dots (NDs) or PML bodies. NDs play a role in autoimmunity, virus infections, and in the etiology of acute promyelocytic leukaemia. SUMO modification of Sp100 has been shown to promote interaction of Sp100 with non-histone chromosomal proteins, suggesting a regulatory role in chromatin organization and in functional interplay between these nuclear bodies and chromatin. |
|
Regulatory Status: | RUO - Research Use Only |
|