| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 292-304 of human SP100, SUMO modified at Lys297. |
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| UniProt ID: | P23497 |
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| Species reactivity: | Human
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| Specificity: | Recognizes human SUMO-Sp100. |
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| Crossreactivity: | Does not cross-react with unmodified Sp100 under native conditions. |
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| Applications: | ICC
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| Formulation: | Liquid. In PBS containing 0.01% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Sp100 is an interferon-inducible protein and a major constituent of distinct nuclear domains, known as nuclear dots (NDs) or PML bodies. NDs play a role in autoimmunity, virus infections, and in the etiology of acute promyelocytic leukaemia. SUMO modification of Sp100 has been shown to promote interaction of Sp100 with non-histone chromosomal proteins, suggesting a regulatory role in chromatin organization and in functional interplay between these nuclear bodies and chromatin. |
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| Regulatory Status: | RUO - Research Use Only |
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