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Tyrphostin 8

Calcineurin inhibitor
BML-PR113-0010 10 mg 106.00 USD
BML-PR113-0050 50 mg 394.00 USD
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Replaces Prod. #: ALX-270-166

The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).

Product Details

Alternative Name:α-Cyano-(4-hydroxy)cinnamonitrile
Purity:≥98% (TLC)
Appearance:Light orange solid.
Solubility:Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling:Store tightly sealed in the dark. Protect from light.
Regulatory Status:RUO - Research Use Only
BML-PR113 structure
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BML-PR113 structure

Product Literature References

Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors: B.L. Martin; Biochem. Pharmacol. 56, 483 (1998), Abstract;
Inhibition of GTP-utilizing enzymes by tyrphostins: G. Wolbring, et al.; J. Biol. Chem. 269, 22470 (1994), Abstract;
Tyrosine phosphorylation is an obligatory event in IL-2 secretion: J.B. Stanley, et al.; J. Immunol. 145, 2189 (1990), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;