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DPPIV/DPP4 inhibitor
BML-PI142-0010 10 mg 126.00 USD
BML-PI142-0050 50 mg 607.00 USD
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P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM. Useful in diabetes research. Has been used in vivo and in tissue culture.

Product Specification

Alternative Name:3-N-[((2S,3S)-2-Amino-3-methylpentanoyl]-1,3-thiazolidine . hemi-fumarate
Formula:C9H18N2OS . 0.5 C4H4O4
Purity:≥98% (TLC, free base)
Appearance:White solid.
Solubility:Soluble in water (20mg/ml) or DMSO (25mg/ml).
Application Notes:May be used to inhibit GLP-1 breakdown in blood, plasma and serum samples at a concentration of 1 mM.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
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Product Literature References

Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats: G. Giannocco, et al.; Eur. J. Pharmacol. 698, 74 (2013), Application(s): Assay using rat skeletal and heart muscle, Abstract;
Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1: R. Crajoinas, et al.; Am. J. Physiol. Renal Physiol. 301, F355 (2011), Application(s): Assay using rat urine and blood, Abstract; Full Text
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats: J.A. Pospisilik, et al.; Diabetes 52, 741 (2003), Application(s): Oral gavage, Abstract; Full Text
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats: J.A. Pospisilik, et al.; Diabetes 51, 943 (2002), Application(s): Oral gavage, Abstract; Full Text

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