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Thrombin inhibitor
BML-PI117-0005 5 mg 194.00 USD
BML-PI117-0025 25 mg 837.00 USD
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Replaces Prod. #: ALX-260-001

Potent irreversible thrombin inhibitor. Inhibits thrombin activation of progelatinase A. Pretreatment with PPACK inhibits thrombin-induced cerebral thromboembolism in vivo.

Product Details

Alternative Name:D-Phe-Pro-Arg-CMK
Purity:≥90% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
BML-PI117 structure
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BML-PI117 structure

Product Literature References

Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia: D. Li, et al.; Mol. Med. Rep. 23, 449 (2021), Abstract; Full Text
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin: L.C. Burzynski, et al.; Immunity 50, 1033 (2019), Abstract;
Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways: I. Lee-Rivera, et al. ; Exp. Eye Res. 139, 81 (2015), Application(s): Thrombin-induced proliferation, Abstract;
Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis: S. Zucker, et al.; J. Biol. Chem. 270, 23730 (1995), Abstract;
Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK): H.B. Rahr, et al.; Thromb. Res. 73, 279 (1994), Abstract;
Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature: J.T. Liu, et al.; Eur. J. Pharmacol. 264, 183 (1994), Abstract;
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin: C. Kettner & E. Shaw; Thromb. Res. 14, 969 (1979), Abstract;

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