Potent inhibitor of human stromelysin-1 (MMP-3), Ki=0.13 µM. Also inhibits MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 (metalloelastase), MMP-13, MMP-14, and MMP-20.
Product Details
| Alternative Name: | N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid |
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| Formula: | C13H20N2O5S |
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| MW: | 316.4 |
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| CAS: | 161314-17-6 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (30mg/ml) or 100% ethanol (8mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase: Y. Arendt et al.; FEBS Lett.
581, 4723 (2007),
Abstract;
A high-affinity carbohydrate-containing inhibitor of matrix metalloproteinases: V. Calderone; Chem. Med. Chem
1, 598 (2006),
Abstract;
Crystal structure of the catalytic domain of human matrix metalloproteinase 10: I. Bertini et al.; J. Mol. Biol.
336, 707 (2004),
Abstract;
Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase: A. Y. Jeng et al.; Bioorg. Med. Chem. Lett.
8, 897 (1998),
Abstract;
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits: L. J. MacPherson et al.; J. Med. Chem.
40, 2525 (1997),
Abstract;
