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Z-prolyl-prolinal

Endopeptidase inhibitor
 
BML-PI112-0005 5 mg 86.00 USD
 
BML-PI112-0025 25 mg 348.00 USD
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A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides.

Product Details

Alternative Name:Z-PP-CHO
 
Sequence:Z-Pro-Pro-CHO
 
Formula:C18H22N2O4
 
MW:330.4
 
CAS:86925-97-5
 
Purity:≥97% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
BML-PI112 structure
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BML-PI112 structure

Product Literature References

Exploring Renal Changes after Bariatric Surgery in Patients with Severe Obesity: A. Oliveras, et al.; J. Clin. Med. 11, 728 (2022), Abstract;
A pressor dose of angiotensin II has no influence on the angiotensin‐converting enzyme 2 and other molecules associated with SARS‐CoV‐2 infection in mice: Y. Wang, et al.; FASEB J. 35, 21419 (2021), Abstract;
Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy: V. Palau, et al.; Int. J. Mol. Sci. 22, 5520 (2021), Abstract;
SARS-CoV-2 Infection Modulates ACE2 Function and Subsequent Inflammatory Responses in Swabs and Plasma of COVID-19 Patients: L. Gutiérrez-Chamorro, et al.; Viruses 13, 1715 (2021), Abstract;

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