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E-64-D

Calpain and cathepsin inhibitor



BML-PI107-0001	1 mg	77.00 USD

BML-PI107-0005	5 mg	323.00 USD
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Cell-permeable, ethyl ester of E-64-c. The ester is hydrolyzed by intracellular esterases to produce E-64-c. Inhibits calpain and cathepsins B, H, and L. Inhibits degradation of autophagic cargo inside autophagolysosomes.

Product Details

Alternative Name:	2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide, Aloxistatin

Formula:	C₁₇H₃₀N₂O₅

MW:	342.4

CAS:	88321-09-9

Purity:	≥98% (HPLC)

Appearance:	White solid.

Solubility:	Soluble in 100% ethanol (>10mg/ml) or DMSO (20mg/ml).

Shipping:	Ambient

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination: C. Blázquez, et al.; Elife 9, 5681 (2021), Abstract; Full Text

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy: M. Dohmen, et al.; Nat. Commun. 11, 1032 (2020), Abstract; Full Text

Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B‐mediated degradation of BRCA1: Y. Wang, et al.; J. Cell. Mol. Med. 23, 1798 (2019), Abstract; Full Text

Mutants of collagen-specific molecular chaperone Hsp47 causing osteogenesis imperfecta are structurally unstable with weak binding affinity to collagen: S. Ito, et al; Biochem. Biophys. Res. Commun. 469, 437 (2016), Application(s): Cell culture, Abstract;

Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality: F.C. Sigloch, et al.; Biochem. Biophys. Acta 1863, 2700 (2016), Application(s): Cell culture; inhibition experiments on U2OS cell line (ATCC), Abstract;

Fatty acids increase adiponectin secretion through both classical and exosome pathways: V. DeClercq, et al.; Biochim. Biophys. Acta 1851, 1123 (2015), Application(s): Cell Culture, Abstract;

Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease: J. Peters, et al.; Biochem. Biophys. Res. Commun. 457, 334 (2015), Application(s): Cell Culture, Abstract;

Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62: D.H. Ball, et al.; J. Parasitol. Res. 2013, 961268 (2013), Abstract; Full Text

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway: P. Waitz, et al.; Autophagy 7, 315 (2011), Application(s): Protease Inhibition for Western Blot samples, Abstract;

Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients: F. Zhou, et al.; PLoS One 6, e22815 (2011), Application(s): Modulation of cultured T-Cells, Abstract; Full Text

Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d: E. B. McGowan et al.; Biochem. Biophys. Res. Commun. 158, 432 (1989), Abstract;

Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai et al.; Chem. Pharm Bull. (Tokyo) 35, 1098 (1987), Abstract;