Replaces Prod. #: ALX-307-038
Activates Ca2+-insensitive PKC isotypes δ, ε and η. Activates Akt/PKB by direct interaction with the Akt PH domain.
Product Details
| Formula: | C41H76O19P3 . 5NH4 |
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| MW: | 966.0 . 90.2 |
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| Purity: | ≥98% (NMR) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in chloroform/methanol/water, 50:50:10 (10mg/ml); not water soluble but resuspends, with vigorous vortexing, to ~0.5 mg/ml in water. See references for method of incorporation into mixed lipid vesicles by sonication, and for dissolving in a detergent-containing buffer. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science
275, 665 (1997),
Abstract;
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K. Klarlund, et al.; Science
275, 1927 (1997),
Application(s): Dissolving in a detergent-containing buffer.,
Abstract;
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem.
269, 32358 (1994),
Application(s): Method of incorporation into mixed lipid vesicles,
Abstract;
