Replaces Prod. #: ALX-340-022
Prostaglandin D2 derived nuclear peroxisome proliferator-activated receptor γ (PPARγ) ligand. Induces apoptosis in a number of cell types including human lung cancer cells, synoviocytes and macrophages. Promotes differentiation of fibroblasts to adipocytes. Antiinflammatory activity. Inhibits angiogenesis. Prevents TNFα induced leptin increase in mice. TRPA1 agonist. Serious doubts as to the biological relevance of this prostaglandin have been raised. Endogenous levels seem to be too low to have any effect as a PPARγ ligand.
Product Details
Alternative Name: | 15-deoxy-Δ12,14-PGJ2 |
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Formula: | C20H28O3 |
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MW: | 316.5 |
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CAS: | 87893-55-8 |
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Purity: | ≥97% (TLC) |
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Appearance: | Neat oil. Vials may appear empty because the oil tends to coat the inside of the vial. |
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Solubility: | Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Handling: | It is recommended to add an appropriate solvent directly to the vial. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
A comparative study of small molecules targeting eIF4A: S.K. Naineni, et al.; RNA
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Abstract;
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Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol.
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Abstract;
Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease: I. Kadiyska; (2016), (PhD thesis);
Application(s): Cell treatment, differentiated Th1 cells,
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Activation of TRPA1 by farnesyl thiosalicylic acid: M. Maher, et al.; Mol. Pharmacol.
73, 1225 (2008),
Abstract;
15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?: W.S. Powell; J. Clin. Invest.
112, 828 (2003),
Abstract;
Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha: B.N. Finck & R.W. Johnson; Am. J. Physiol. Regul. Integr. Comp. Physiol.
282, R1429 (2002),
Abstract;
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages: A.A. Von Knethen, et al.; FASEB J.
15, 535 (2001),
Abstract;
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats: Y. Kawahito, et al.; J. Clin. Invest.
106, 189 (2000),
Abstract;
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis: Y. Tsubouchi, et al.; Biochem. Biophys. Res. Commun.
270, 400 (2000),
Abstract;
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem.
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Abstract;
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma: P.W. Young, et al.; J. Pharmacol. Exp. Ther.
284, 751 (1998),
Abstract;
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines: C. Jiang, et al.; Nature
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Abstract;
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell
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Abstract;
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation: S.A. Kliewer, et al.; Cell
83, 813 (1995),
Abstract;
9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma: Y. Kikawa, et al.; Proc. Natl. Acad. Sci. USA
81, 1317 (1984),
Abstract;
Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro: F.A. Fitzpatrick & M.A. Wynalda; J. Biol. Chem.
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