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Prostaglandin A2

CDK inhibitor
BML-PG002-0010 10 mg 250.00 USD
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Replaces Prod. #: ALX-340-047

Blocks cell cycle at the G1 and G2/M phase [1] by inhibiting G1 phase cyclin dependent kinases [2] downregulating cyclin D1 [3]. Modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, glutathione S-transferase activity and transport of GSH conjugates [4]. Antitumor activity. Induces γ-glutamylcysteine synthetase and apoptosis in L-1210 cells.

Product Specification

Alternative Name:Medullin, Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5Z,13E,15S)-, PGA2
Purity:≥98% (TLC)
Appearance:Neat oil.
Solubility:Soluble in 100% ethanol, acetone or ethyl acetate.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
Handling:Store at -20°C or colder. For experiments with cells or tissues, dissolve in ethanol and add aliquots directly to aqueous media. For HPLC, aliquots in acetone solution should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration. Avoid basic conditions.
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Product Literature References

Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover: S. Lin, et al.; Mol. Cell. Biol. 20, 7903 (2000), Abstract; Full Text
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system: M.L. van Iersel, et al.; Biochem. Pharmacol. 57, 1383 (1999), Abstract;
p21Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation: M. Hitomi, et al.; Oncogene 17, 959 (1998), Abstract;
Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation: M. Hitomi, et al.; J. Biol. Chem. 271, 9376 (1996), Abstract; Full Text
Prostaglandin A2 and delta 12-prostaglandin J2 induce apoptosis in L1210 cells: I.K. Kim, et al.; FEBS Lett. 321, 209 (1993), Abstract;
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini, et al.; Br. J. Cancer 61, 394 (1990), Abstract;
Induction of gamma-glutamylcysteine synthetase by prostaglandin A2 in L-1210 cells: K. Ohno & M. Hirata; Biochem. Biophys. Res. Commun. 168, 551 (1990), Abstract;
Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved: M. Fukushima; Eicosanoids 3, 189 (1990), Abstract;

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