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Prostaglandin A1

Prostanoid receptor ligand
BML-PG001-0010 10 mg 340.00 USD
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Replaces Prod. #: ALX-340-045

Biosynthesis from dihomo-γ-linolenic acid. Stimulates renin release. Antitumor activity. Inhibits NFκB activation in several human cell lines. Induces the synthesis of heat shock proteins. Activates PPARs in human osteosarcoma cells at 10μM.

Product Details

Alternative Name:PGA1
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in 100% ethanol (50mg/ml), DMSO (50mg/ml) or PBS pH7.2 (2.4mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase: A. Rossi et al.; Nature 403, 103 (2000), Abstract;
Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation: A. Rossi et al.; Proc. Natl. Acad. Sci. USA 94, 746 (1997), Abstract;
Modulation of prostaglandin A1-induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70: G. Elia et al.; Cancer Res. 56, 210 (1996), Abstract;
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu et al.; J. Biol. Chem. 270, 23975 (1995), Abstract;
Induction of thermotolerance by prostaglandin A in human cells: C. Amici et al.; Exp. Cell Res. 207, 230 (1993), Abstract;
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini et al.; Br. J. Cancer 61, 394 (1990), Abstract;
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism: J. Hahn et al.; Prostaglandins 20, 15 (1980), Abstract;