Potent (IC50=40nM) and selective (290X selectivity over other PDE isoforms) inhibitor of phosphodiesterase Type II (PDE2). Displayed no significant level of binding to neither a collection of 54 receptors and ion channels, nor to a panel of 30 kinases. BML-288 demonstrated no inhibition of 5-lipoxygenase (5-LO) or cyclooxygenase (COX-1). BML-288 is more potent and selective than EHNA (BML-PD129).
Product Details
| Alternative Name: | 5-Methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-7H-furo[2,3-f]indole-7-carboxamide |
| |
| Formula: | C14H10N4O3S |
| |
| MW: | 314.3 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | Off-white solid. |
| |
| MeltingPoint: | 243-245°C |
| |
| Solubility: | Soluble in DMSO (25 mg/ml). |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Store under inert gas. Compound will darken on exposure to air. Stable for at least 1 year after the date of reciept when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
| |
| Handling: | Solutions can be stored at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A new chemical tool for exploring the physiological function of the PDE2 isozyme: R. Chambers, et al.; Bioorg. Med. Chem. Lett.
16, 307 (2006),
Abstract;
Related Products
