Replaces Prod. #: ALX-270-150
Selective inhibitor of Ca2+/calmodulin-dependent phosphodiesterase (PDE I, IC50=20 µM).
Product Details
| Formula: | C22H26N2O2 |
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| MW: | 350.5 |
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| CAS: | 42971-09-5 |
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| MI: | 14: 9991 |
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| RTECS: | JW4792000 |
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| Purity: | ≥98% (Assay) |
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| Identity: | Determined by IR. |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in DMSO or acetone. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors: K. Molnar-Kimber, et al.; Agents Actions
39, C77 (1993),
Abstract;
Cyclic 3’,5’-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells: M. Yamaki, et al.; Am. J. Physiol.
262, F957 (1992),
Abstract;
Regulation of cyclic AMP metabolism in bovine adrenal medullary cells: P.D. Marley & K.A. Thomson; Biochem. Pharmacol.
44, 2105 (1992),
Abstract;
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol.
38, 3331 (1989),
Abstract;
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle: M. Hagiwara, et al.; Biochem. Pharmacol.
33, 453 (1984),
Abstract;
