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PDE inhibitor
BML-PD180-0010 10 mg 370.00 USD
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Replaces Prod. #: ALX-270-126

Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC50=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.

Product Details

Alternative Name:9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl, HL 725
Formula:C24H27N3O3 . HCl
MW:405.5 . 36.5
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR and LC-MS.
Appearance:White to pale yellow solid.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml); slightly soluble in water.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Solutions are stable for up to 3 months when stored at -20°C.
Handling:Protect from moisture.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth: R. An, et al.; Am. J. Cancer Res. 9, 1905 (2019), Abstract; Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991), Abstract;
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990), Abstract;
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990), Abstract; Full Text
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982), Abstract;

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