Replaces Prod. #: ALX-270-119
Selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=1 µM). A rolipram insensitive PDE IV subtype has been described.
Product Details
| Alternative Name: | (±)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
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| Formula: | C16H21NO3 |
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| MW: | 275.4 |
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| CAS: | 61413-54-5 |
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| MI: | 14: 8251 |
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| RTECS: | UY5749237 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or acetone. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 5 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock: X. Lu, et al.; Sci. Rep.
10, 175 (2020),
Abstract;
Full Text
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis: Y. Qiu, et al.; Cell Death Dis.
10, 547 (2019),
Abstract;
Full Text
Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways: H. Yu, et al.; Int. J Mol. Sci.
19, 513 (2018),
Abstract;
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper): Y. Pang & P. Thomas; Gen. Comp. Endocrinol.
265, 180 (2018),
Abstract;
Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin: Z. Wang, et al.; Sci. Rep.
5, 12012 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors: F. Mullershausen, et al.; Nat. Chem. Biol.
5, 428 (2009),
Abstract;
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther.
270, 250 (1994),
Abstract;
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol.
42, 679 (1991),
Abstract;
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J.
241, 535 (1987),
Abstract;
Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol.
127, 105 (1986),
Abstract;
