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PDE inhibitor
BML-PD175-0010 10 mg 87.00 USD
BML-PD175-0050 50 mg 373.00 USD
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Replaces Prod. #: ALX-270-119

Selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=1 µM). A rolipram insensitive PDE IV subtype has been described.

Product Details

Alternative Name:(±)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
MI:14: 8251
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or acetone.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 5 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock: X. Lu, et al.; Sci. Rep. 10, 175 (2020), Abstract; Full Text
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis: Y. Qiu, et al.; Cell Death Dis. 10, 547 (2019), Abstract; Full Text
Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways: H. Yu, et al.; Int. J Mol. Sci. 19, 513 (2018), Abstract;
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper): Y. Pang & P. Thomas; Gen. Comp. Endocrinol. 265, 180 (2018), Abstract;
Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin: Z. Wang, et al.; Sci. Rep. 5, 12012 (2015), Application(s): Cell Culture, Abstract; Full Text
Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors: F. Mullershausen, et al.; Nat. Chem. Biol. 5, 428 (2009), Abstract;
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs: D.C. Underwood, et al.; J. Pharmacol. Exp. Ther. 270, 250 (1994), Abstract;
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, et al.; Biochem. Pharmacol. 42, 679 (1991), Abstract;
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors: M.L. Reeves, et al.; Biochem. J. 241, 535 (1987), Abstract;
Stereospecific binding of the antidepressant rolipram to brain protein structures: H.H. Schneider, et al.; Eur. J. Pharmacol. 127, 105 (1986), Abstract;

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