Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50=2 µM).
Product Details
| Alternative Name: | Etazolate |
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| Formula: | C14H19N5O2 . HCl |
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| MW: | 325.8 |
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| CAS: | 35838-58-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to pale yellow solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store as supplied, at room temperature, for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes et al.; Cell. Signal.
5, 615 (1993),
Abstract;
Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction: G.S. Ahluwalia et al.; Biochem. Pharmacol.
31, 665 (1982),
Abstract;
