Phosphodiesterase PDE II inhibitor, IC50=0.8 µM. Also inhibits adenosine deaminase, Ki=4 nM.
Product Details
Alternative Name: | Erythro-9-(2-hydroxy-3-nonyl)adenine . HCl |
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Formula: | C14H23N5O . HCl |
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MW: | 313.8 |
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CAS: | 51350-19-7 |
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Purity: | ≥98% (HPLC) |
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Appearance: | White solid. |
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Solubility: | Soluble in water (25mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes: P.F. Mery, et al.; Mol. Pharmacol.
48, 121 (1995),
Abstract;
Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine: T. Podzuweit, et al.; Cell. Signal.
7, 733 (1995),
Abstract;
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition: M. Bessodes, et al.; Biochem. Pharmacol.
31, 879 (1982),
Abstract;