Replaces Prod. #: ALX-270-404
Phosphodiesterase PDE3 inhibitor (IC50=5 nM). Blocks PKB/Akt signaling pathway by inhibition of Akt-activated PDE3B. Reverses the established effects of leptin on food intake and body weight. Blocks the leptin-induced tyrosine phosphorylation of STAT3 at the hypothalamic level.
Product Details
| Alternative Name: | OCP 3689, OPS 3689, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide |
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| Formula: | C20H26N2O3 |
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| MW: | 342.4 |
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| CAS: | 68550-75-4 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light and oxygen. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper): Y. Pang & P. Thomas; Gen. Comp. Endocrinol.
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Abstract;
Cilostamide and forskolin treatment during pre-IVM improves preimplantation development of cloned embryos by influencing meiotic progression and gap junction communication in pigs: B. Park, et al.; Theriogenology
86, 757 (2016),
Abstract;
Immature Oocytes from Unprimed Juvenile Mice Become a Valuable Source for Embryo Production When Using C-Type Natriuretic Peptide as Essential Component of Culture Medium: S. Romero, et al.; Biol. Reprod.
95, 64 (2016),
Application(s): Comparative developmental capacity of oocytes undergoing Pre-IVM in presence of CNP or an inhibitor of phosphodiesterase type 3 (PDE3-I),
Abstract;
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Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation: M. Shelly, et al.; Science
327, 547 (2010),
Abstract;
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding: A.Z. Zhao, et al.; Nat. Neurosci.
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Abstract;
Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells: F. Ahmad, et al.; J. Immunol.
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Abstract;
Protein kinase B/Akt induces resumption of meiosis in Xenopus oocytes: C.B. Andersen, et al.; J. Biol. Chem.
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Abstract;
Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase--basic and potential clinical applications: H. Hidaka & T. Endo; Adv. Cyclic Nucleotide Protein Phosphorylation Res.
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Abstract;
