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DP-AMC

DPP substrate
 
BML-P449-0005 5 mg 98.00 USD
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Fluorogenic substrate cleaved by dipeptidyl peptidase IV (DPIV, DPPIV, CD26) (Km=28µM, kcat/Km=3.7 x 103M-1s-1), DPPII/VII (Km=1.12mM, kcat/Km=40.0 M-1s-1), and likely DPP8 and other prolyl peptidases. Can be used in vitro, for inhibitor screening, and in biological fluids. Ex = 380 nm, Em = 460 nm.

Product Specification

Alternative Name:Asp-Pro-AMC
 
Sequence:H-Asp-Pro-AMC
 
MW:387.4
 
Formulation:Lyophilized.
 
Purity:≥95% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Isoaspartate residues dramatically influence substrate recognition and turnover by proteases: L. Böhme, et al.; Biol. Chem. 389, 1043 (2008), Abstract;
Investigation of the dimer interface and substrate specificity of prolyl dipeptidase DPP8: H.-J. Lee, et al.; J. Biol. Chem. 281, 38653 (2006), Abstract;
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity: C.Y. Edosada, et al.; J. Biol. Chem. 281, 7437 (2006), Abstract; Full Text
Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7): M.B. Maes, et al.; Biochem. J. 386, 315 (2005), Abstract; Full Text

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