Replaces Prod. #: ALX-260-039
Irreversible and cell permeable broad-spectrum caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). For cell free assays use Prod. No. ALX-260-020.
Product Details
Alternative Name: | Caspase family inhibitor (fluoromethylketone) |
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Sequence: | Z-Val-Ala-Asp(OMe)-fluoromethylketone |
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Formula: | C22H30N3O7F |
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MW: | 467.5 |
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CAS: | 187389-52-2 |
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Purity: | ≥95% |
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Appearance: | White to off-white solid. |
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Application Notes: | Irreversible, cell permeable, broad spectrum caspase inhibitor. Limited Fas-induced mouse liver damage and apoptosis to <1%, at a dose of 50µmol/kg. At 50µM, abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells. |
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Solubility: | Soluble in DMSO (>10mg/ml), dimethyl formamide (7mg/ml) or 100% ethanol (1.3mg/ml). |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month. |
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Handling: | Keep cool and dry. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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