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pp60c-src C-terminal phosphoregulatory peptide

Src kinase inhibitor
 
BML-P301-0001 1 mg 265.00 USD
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This phosphopeptideis the C-terminal negative regulatory domain of c-Src (521-533) which includes the negative regulatory site (Tyr527). This peptide, when tyrosine-phosphorylated, binds to the internal SH2 domain.

Product Details

Alternative Name:[pTyr527] c-Src (521-533)
 
Sequence:Ac-Thr-Ser-Thr-Glu-Pro-Gln-pTyr-Gln-Pro-Gly-Glu-Asn-Leu
 
MW:1585.7
 
Purity:≥98%
 
Appearance:Lyophilized solid.
 
Solubility:Soluble in Water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis: D. Thompson, et al.; Clin. Sci. (Lond.) 131, 2489 (2017), Abstract;
Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats: P.K. Picardi, et al.; Endocrinology 149, 3870 (2008), Abstract; Full Text
Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration: Y. Izawa, et al.; Hypertens. Res. 20, 1107 (2007), Abstract;
Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4): B. Lu, et al.; J. Biol. Chem. 276, 35589 (2001), Abstract;

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