Highly sensitive substrate for neutrophil elastase (leukocyte elastase) (Km=130 µM), but not granzyme H. This substrate can be used for in vitro assays with purified enzyme, on live cells, or in conditioned medium. Ex: 380 nm, Em: 460 nm.
Product Details
| Alternative Name: | Neutrophil elastase substrate (fluorogenic) |
| |
| Sequence: | N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin |
| |
| Formula: | C31H41N5O9 |
| |
| MW: | 627.7 |
| |
| CAS: | 72252-90-5 |
| |
| Purity: | ≥95% (HPLC) |
| |
| Appearance: | White solid |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Midgut serine proteases and alternative host plant utilization in Pieris brassicae L: R. Kumar, et al.; Front. Physiol.
6, 95 (2019),
Abstract;
A secretory leukocyte protease inhibitor variant with improved activity against lung infection: N. Camper, et al.; Mucosal Immunol.
9, 669 (2016),
Abstract;
