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R18 peptide

14-3-3 inhibitor
BML-P214-0001 1 mg 249.00 USD
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The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments. A biotinylated form is available (BML-P225), allowing detection using streptavidin.

Product Details

Formulation:Lyophilized. Trifluoroacetate salt.
Purity:≥95% (HPLC)
Identity:Determined by MS.
Solubility:Soluble in Water.
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only

Product Literature References

Bacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin: S.H. Park, et al.; Cell Death Dis. 11, 231 (2020), Abstract; Full Text

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