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MeOSuc-AAPV-pNA

Substrate for neutrophil elastase and neutrophil proteinase 3
 
BML-P213-0005 5 mg 92.00 USD
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Highly sensitive substrate for human and mouse neutrophil elastase (leukocyte elastase) and neutrophil proteinase 3 (PR-3, myeloblastin), but not cathepsin G nor chymotrypsin. This substrate can be used for in vitro assays with purified enzyme, or with biological fluids or conditioned medium. Hydrolysis of the substrate can be detected at 405-410 nm.

Product Specification

Sequence:N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
 
MW:590.6
 
CAS:70967-90-7
 
Purity:≥98%
 
Solubility:Soluble in DMSO (>20 mM) or methanol (1 mg/mL).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin: D.S. John, et al.; J. Biol. Chem. 294, 697 (2019), Abstract;
Competitive neutrophil elastase inhibitory isoflavones from the roots of Flemingia philippinensis: J.Y. Kim, et al.; Bioorg. Chem. 78, 249 (2018), Abstract;
The putative role of Rhipicephalus microplus salivary serpins in the tick-host relationship: L. Tirloni, et al.; Insect Biochem. Mol. Biol. 71, 12 (2016), Application(s): Used for proteinase-3, Abstract;
Engineering D-helix of antithrombin in alpha-1-proteinase inhibitor confers antiinflammatory properties on the chimeric serpin: L. Yang, et al.; Thromb. Haemost. 112, 164 (2014), Abstract; Full Text

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