Sequence is from Ca2+/calmodulin-dependent kinase A subunit negative regulatory sequence containing the calmodulin binding site (290-309) plus autophosphorylation site (Thr286). Peptide can be phosphorylated at Thr286 by PKC. Useful as a CaM binding peptide and inhibits CaMKII by blocking Ca2+/CaM activation and the enzyme active-site. IC50=80 nM, CaM binding; IC50=2 µM, active-site.
Product Details
| Alternative Name: | CaMKII (281-309), Ca2+/calmodulin-dependent protein kinase II (281-309) |
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| Sequence: | Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala |
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| MW: | 3374.5 |
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| Purity: | ≥97% |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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