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Z-GPR-AMC

Cathepsin K substrate
 
BML-P142-0020 20 mg 313.00 USD
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Fluorogenic substrate specific for cathepsin K, among other cathepsin family members. This substrate is also cleaved by granzyme A, thrombin, tryptase, trypsin, and kallikreins. Ex.: 365 nm, Em.: 440 nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Specification

Alternative Name:Z-Gly-Pro-Arg-AMC
 
Sequence:Z-Gly-Pro-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
 
MW:656.1
 
Formulation:C31H37N7O7
 
Purity:≥97% (HPLC)
 
Appearance:White powder.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress: H. Kristen, et al.; Neurobiol. Aging 68, 5 (2018), Abstract;
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study: A. Denadai-Souza, et al.; Arthritis Res. Ther. 19, 124 (2017), Abstract; Full Text
Upconversion nanocarriers encapsulated with photoactivatable Ru complexes for near‐infrared light‐regulated enzyme activity: Z. Chen, et al.; Small 13, (2017), Abstract;
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L.(Coleoptera: Curculionidae): S. Ben-Mahmoud, et al.; J. Insect Physiol. 72, 1 (2015), Abstract;
Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells: P. Xu, et al.; J. Ocul. Pharmacol. Ther. 30, 246 (2014), Abstract; Full Text
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract; Full Text
Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis: K. Porter, et al.; Autophagy 9, 581 (2013), Abstract; Full Text

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