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Cathepsin substrate
BML-P141-0025 25 mg 105.00 USD
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Chromogenic substrate cleaved by cathepsin G, subtilisins, chymotrypsin, chymase, and cyclophilins, but not neutrophil elastase. Release of pNA is monitored at 405-410 nm. This substrate is useful for inhibitor screening and kinetic analysis. Also available: calibration standard pNA (BML-KI145).

Product Details

Alternative Name:Suc-Ala-Ala-Pro-Phe-pNA
Sequence:Suc-Ala-Ala-Pro-Phe-pNA [Suc=succinyl; pNA=p-nitroanilide]
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
Chymase-dependent production of angiotensin II: an old enzyme in old hearts: G. Froogh, et al.; Am. J. Physiol. Heart Circ. Physiol. 312, H223 (2017), Abstract;
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L.(Coleoptera: Curculionidae): S. Ben-Mahmoud, et al.; J. Insect Physiol. 72, 1 (2015), Abstract;

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