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Cathepsin substrate
BML-P137-0010 10 mg 115.00 USD
BML-P137-0050 50 mg 554.00 USD
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Fluorogenic substrate specific for cathepsin B (kcat/Km=105 M-1s-1). The following proteases do not cleave, or inefficiently cleave, this substrate: papain, cathepsins C/DPP-I, F, H, K/O2, L, L2/V, O, S, X/Z. Ex.: 365 nm, Em.: 440 nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for analysis of cathepsin B activity in cell extracts, inhibitor screening, and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Details

Alternative Name:Z-Arg-Arg-AMC
Sequence:Z-Arg-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis: A. Di Spiezio, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166205 (2021), Abstract;
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress: H. Kristen, et al.; Neurobiol. Aging 68, 5 (2018), Abstract;
Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo: L. Li, et al.; Toxicol. Appl. Pharmacol. 310, 175 (2016), Abstract;
BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts: M. Tatti, et al.; Hum. Mol. Genet. 24, 4198 (2015), Abstract;
Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells: P. Xu, et al.; J. Ocul. Pharmacol. Ther. 30, 246 (2014), Abstract; Full Text
Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex: C. Hiebel, et al.; J. Neurochem. 131, 484 (2014), Abstract;
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract; Full Text

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