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TACE substrate (fluorogenic)

BML-P132-0500 0.5 mg 174.00 USD
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Item sold as 0.5mg net peptide.

Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).

Product Details

Alternative Name:ADAM17 substrate
[Mca=(7-methoxycoumarin-4-yl)acetyl; Dpa=N-3(2,4-dinitrophenyl)-L-α,β-diaminopropionyl]
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke: D.M. Bennion, et al.; J. Renin Angiotensin Aldosterone Syst. 17, 1470320316661060 (2016), Abstract; Full Text

Related Products

OMNIMMP® fluorogenic control 

140430-55-3, Synthetic., ≥98% (TLC) | Print as PDF
BML-P127-0001 1 mg 92.00 USD
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