This sequence, KKRAARATSDVFA, is chicken gizzard smooth muscle myosin P-light chain (MLC 11-23) with Pro to Ala14 and Gln to Ala15 substitutions. Contains specificity determinants for MLC phosphorylation (target is Ser19) and is an excellent myosin light chain kinase (MLCK) substrate. Km=8.6 µM for rabbit skeletal muscle MLCK, 7.5 µM for chicken gizzard smooth muscle MLCK.
Product Details
| Alternative Name: | Myosin light chain kinase substrate, Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2 |
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| Sequence: | Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH2 |
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| MW: | 1418.0 |
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| Source: | Synthetic. |
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| Formulation: | Lyophilized. |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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