Replaces Prod. #: ALX-160-006
Phosphate acceptor peptide. Substrate for Ser/Thr protein kinases. Km=4.7µM for cAMP-dependent protein kinase (PKA). The sequence defines the phosphorylation site of porcine liver pyruvate kinase.
Product Details
| Sequence: | H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH |
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| Formula: | C32H61N13O9 |
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| MW: | 771.9 |
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| CAS: | 65189-71-1 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥97% (HPLC) |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Replacement for ADI-SPK-101 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ischemia-induced translocation of Ca2+/calmodulin-dependent protein kinase II: potential role in neuronal damage: J. Aronowski, et al.; J. Neurochem.
58, 1743 (1992),
Abstract;
Assays of protein kinase: R. Roskoski; Methods Enzymol.
99, 3 (1983),
Abstract;
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase: J.R. Feramisco, et al.; J. Biol. Chem.
255, 4240 (1980),
Abstract;
Full Text
Adrenergic control of the cyclic AMP-dependent protein kinase and pyruvate kinase in isolated hepatocytes. Application of a synthetic peptide substrate for measuring protein kinase activity: B.E. Kemp & M.G. Clark; J. Biol. Chem.
253, 5147 (1978),
Abstract;
Full Text
In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP- dependent protein kinase: J.L. Maller, et al.; PNAS
75, 248 (1978),
Abstract;
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase: B.E. Kemp, et al.; J. Biol. Chem.
252, 4888 (1977),
Abstract;
Full Text
Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase: A.H. Pomerantz, et al.; PNAS
74, 4261 (1977),
Abstract;
Synthetic peptide substrates of the cAMP-dependent protein kinase: B.E. Kemp, et al.; Fed. Proc. 35, 1384 (1976),
