Replaces Prod. #: ALX-167-007
Phosphorylation site 2 of glycogen synthase containing the R-X-X-S/T consensus phosphorylation site within the sequence, PLARTLSVAGLPKK. Substrate for CaMKII (Km =12 µM) with purified enzyme or in cell extracts using TCA/phosphocellulose assay. Substrate for other kinases, therefore inhibitors must be used to discern activity. Reported substrate for Raf-1.
Product Details
| Sequence: | H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH |
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| Formula: | C68H122N20O18 |
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| MW: | 1507.8 |
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| CAS: | 108334-68-5 |
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| Formulation: | Lyophilized. Counter Ion: Trifluoroacetate salt |
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| Purity: | ≥97% (HPLC) |
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| Solubility: | Soluble in water. |
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| Reconstitution: | Reconstitute in sterile, distilled water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide: Y. Hashimoto & T. R. Soderling; Arch. Biochem. Biophys.
252, 418 (1987),
Abstract;
General Literature References
Enzymatic characteristics of the c-Raf-1 protein kinase.: T. Force et al.; PNAS
91, 1270 (1994),
Abstract;
Full Text
Raf-1: a kinase currently without a cause but not lacking in effects.: P. Li et al.; Cell
64, 479 (1991),
Abstract;
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.: U. R. Rapp; Oncogene
6, 495 (1991),
Abstract;
