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Paroxetine . HCl

Highly potent and selective serotonin uptake inhibitor
BML-NS710-0020 20 mg 108.00 USD
BML-NS710-0100 100 mg 427.00 USD
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Paroxetine is a highly potent and selective serotonin (5-HT) uptake inhibitor. It acts by binding to the serotonin transporter (SERT) with high affinity (Ki = 05 nM). In vitro paroxetine competitively inhibits the uptake of 5-HT by rat hypothalamic and cortical synaptosomes with only very weak effects on noradrenaline and dopamine uptake. Paroxetine is in clinical use for the treatment of depression, anxiety and other disorders.

Product Details

Alternative Name:Paxil®, Paroxetine . HCl . hemihydrate
Formula:C19H20FNO3 . HCl . 1/2 H2O
CAS:110429-35-1; 78246-49-8; 61869-08-7 (free base)
Purity:≥98% (UHPLC)
Appearance:White to off-white crystalline solid.
Solubility:Soluble in DMSO (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
BML-NS710 structure
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BML-NS710 structure

Product Literature References

Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine: J. Fujishiro, et al.; Eur. J. Pharmacol. 454, 183 (2002), Abstract;
Paroxetine: a review: M. Bourin, et al.; CNS Drug Rev. 7, 25 (2001), Abstract;
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites: M.J. Owens, et al.; J. Pharmacol. Exp. Ther. 283, 1305 (1997), Abstract; Full Text
Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor: D.R. Thomas, et al.; Psychopharmacol. 93, 193 (1987), Abstract;

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