Selective serotonin 5-HT2C agonist. Displays antiaversive effects in a panic-like anxiety rat model. May display appetite regulating properties similar to other 5-HT2C agonists.
Product Details
| Alternative Name: | 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine |
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| Formula: | C10H11ClF3N3 |
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| MW: | 265.7 |
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| CAS: | 210821-63-9 |
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| Purity: | ≥95% (NMR) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity: J.C. Halford, et al.; Curr. Drug Targets
6, 201 (2005),
Abstract;
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells: R.H. Porter, et al.; Br. J. Pharmacol.
128, 13 (1999),
Abstract;
Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats: F. Jenck, et al.; Eur. Neuropsychopharmacol.
8, 161 (1998),
Abstract;
