Inhibits dopamine and norepinephrine transporters (Ki=2.8 and 1.4µM respectively). Inhibits the serotonin transporter at higher concentration (Ki=45µM). In clinical use as an antidepressant and for smoking cessation. Also acts as a nicotinic receptor antagonist.
Product Details
| Formula: | C13H18ClNO . HCl |
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| MW: | 276.2 |
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| CAS: | 31677-93-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (>25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Full Text
Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo: B.R. Cooper, et al.; J. Pharmacol. Exp. Ther.
215, 127 (1980),
Abstract;
