Major metabolite of clozapine. Potent serotonin 5-HT1c receptor antagonist.
Product Details
Alternative Name: | Norclozapine |
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Formula: | C17H17ClN4 |
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MW: | 312.8 |
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CAS: | 6104-71-8 |
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Purity: | ≥99% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | Yellow solid. |
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Solubility: | Soluble in ethanol (25 mg/ml) or DMSO (>44 mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther.
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Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol.
245, 179 (1993),
Abstract;
On-line fully automated determination of clozapine and desmethylclozapine in human serum by solid-phase extraction on exchangeable cartridges and liquid chromatography using a methanol buffer mobile phase on unmodified silica: O.V. Olesen & B. Poulsen; J. Chromatog.
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Abstract;